Science behind Netra Restoration Therapy (NRT)
Most eye diseases have multi-factorial causes and have multiple pathways concurrently at interplay affecting retinal cells and other ocular tissues.
These multi-factorial causes are neurotropic deprivation, vascular dysregulation, ocular inflammation, oxidative stress, antioxidant deprivation and ocular excitotoxicity.
Targeting only one of these causes in a treatment protocol would not yield good results as the other active factors could overpower the improvements seen.
Treatments should address all of these factors simultaneously to obtain successful results.
NRT exhibits multi-component, multi-pathway and multi-target synergistic mechanism of action to address all these multi-factorial causes simultaneously for successful treatment of many ocular disorders.
NRT exhibits multi-component, multi-pathway and multi-target synergistic mechanism of action for the treatment of ocular disorders.
Multi-pathway mechanism of action (MOA) of NRT
Science behind Netra Restoration Therapy (NRT)
Most eye diseases have multi-factorial causes and have multiple pathways concurrently at interplay affecting retinal cells and other ocular tissues.
These multi-factorial causes are neurotropic deprivation, vascular dysregulation, ocular inflammation, oxidative stress, antioxidant deprivation and ocular excitotoxicity.
Targeting only one of these causes in a treatment protocol would not yield good results as the other active factors could overpower the improvements seen.
Treatments should address all of these factors simultaneously to obtain successful results.
Multi-pathway mechanism of action (MOA) of NRT
Neurotrophins helps to provide the required neuroprotection which prevents death of the ganglion cells in the retina.
Neuroprotection
Brain-Derived Neurotrophic Factor (BDNF) is a potent neuroprotectant required for survival of retinal neurons. Studies have shown that there is significant reduction in BDNF in patients with eye diseases and this contributes to the degeneration of the retinal cells.
Over the last decade there had been many scientific researches around the world which showed how BDNF neuroprotection plays an important role in the protection of the retinal cells from damage when its subjected to injury.
Neuroprotection is being studied by scientist in an attempt to eradicate or slow down the optic neuro degeneration.
The deprivation of neurotrophins has been shown to play a crucial role in the loss of retinal ganglion cells and its axons and pre-clinical studies have demonstrated that neurotrophins promote retinal ganglion cells recovery and regrowth.
Neuro-protection helps protect neurons in your eye from external and internal injury. Neurotrophins helps to provide the required neuroprotective therapy which prevents from death of the ganglion cells in your eyes.
Neuroprotection works by preventing ischemia and oxidative damage that results in apoptosis of retinal ganglion cells and optic nerve damage. Herbals supplements in Netra Restoration Therapy offers neuroprotection by anti-apoptosis, pro-inflammatory mediator inhibitory, autophagy regulatory, anti-oxidative stress, mitochondria protection, Ca2+ influx inhibitory, and anti-neurodegenerative activities.
As an example, Puerarin a compound derived from pueraria lobata (herb from Traditional Chinese Medicine) has been shown to offer neuroprotection for many neuro degenerative eye conditions such as Glaucoma, Age-Related Macular Degeneration and Diabetic Retinopathy, Retinitis Pigmentosa, Macular Dystrophy and Stargardt disease.
Neuroprotection
Brain-Derived Neurotrophic Factor (BDNF) is a potent neuroprotectant required for survival of retinal neurons. Studies have shown that there is significant reduction in BDNF in patients with eye diseases and this contributes to the degeneration of the retinal cells.
Over the last decade there had been many scientific researches around the world which showed how BDNF neuroprotection plays an important role in the protection of the retinal cells from damage when its subjected to injury.
Neuroprotection is being studied by scientist in an attempt to eradicate or slow down the optic neuro degeneration.
The deprivation of neurotrophins has been shown to play a crucial role in the loss of retinal ganglion cells and its axons and pre-clinical studies have demonstrated that neurotrophins promote retinal ganglion cells recovery and regrowth.
Neuro-protection helps protect neurons in your eye from external and internal injury. Neurotrophins helps to provide the required neuroprotective therapy which prevents from death of the ganglion cells in your eyes.
Neuroprotection works by preventing ischemia and oxidative damage that results in apoptosis of retinal ganglion cells and optic nerve damage. Herbals supplements in Netra Restoration Therapy offers neuroprotection by anti-apoptosis, pro-inflammatory mediator inhibitory, autophagy regulatory, anti-oxidative stress, mitochondria protection, Ca2+ influx inhibitory, and anti-neurodegenerative activities.
As an example, Puerarin a compound derived from pueraria lobata (herb from Traditional Chinese Medicine) has been shown to offer neuroprotection for many neuro degenerative eye conditions such as Glaucoma, Age-Related Macular Degeneration and Diabetic Retinopathy, Retinitis Pigmentosa, Macular Dystrophy and Stargardt disease.
Photoreceptors, especially cones, have high energy demands, making them vulnerable to metabolic stress. Metabolic dysfunction of photoreceptors and their supporting retinal pigment epithelium (RPE) is an important underlying cause of degenerative retinal diseases.
Li B, Zhang T, Liu W, et al. Metabolic Features of Mouse and Human Retinas: Rods versus Cones, Macula versus Periphery, Retina versus RPE. iScience. 2020;23(11):101672. Published 2020 Oct 14. doi:10.1016/j.isci.2020.101672
Vision loss in glaucoma is not only associated with elevated intraocular pressure and neurodegeneration, but vascular dysregulation is also a major factor.
Ocular Blood Flow
Reduction in ocular blood flow leads to unstable ocular perfusion and many research studies have shown that in many eye diseases there is reduced ocular blood flow and perfusion. Vascular dysregulation seems to be cause of this reduced ocular blood flow.
Vascular dysregulation refers to a condition where there is inappropriate constriction or insufficient dilation of the micro vasculature in response to irritation like cold provocation or emotional stress.
People who suffer from vascular dysregulation often experience variant degrees of migraine, cold extremities, and low blood pressure. Vascular dysregulation has been reported to be a risk factor for many eye diseases, especially open angle glaucoma.
Vascular dysregulation means that blood flow is not properly flowing. This causes reduced and unstable oxygen supply to the tissues in the eyes. This in turn causes a cascade of events causing ocular inflammation, reduced outflow of metabolic waste and atrophy of the retinal cells.
Ocular Blood Flow
Reduction in ocular blood flow leads to unstable ocular perfusion and many research studies have shown that in many eye diseases there is reduced ocular blood flow and perfusion. Vascular dysregulation seems to be cause of this reduced ocular blood flow.
Vascular dysregulation refers to a condition where there is inappropriate constriction or insufficient dilation of the micro vasculature in response to irritation like cold provocation or emotional stress.
People who suffer from vascular dysregulation often experience variant degrees of migraine, cold extremities, and low blood pressure. Vascular dysregulation has been reported to be a risk factor for many eye diseases, especially open angle glaucoma.
Vascular dysregulation means that blood flow is not properly flowing. This causes reduced and unstable oxygen supply to the tissues in the eyes. This in turn causes a cascade of events causing ocular inflammation, reduced outflow of metabolic waste and atrophy of the retinal cells.
Recent evidence has shown ocular inflammation as a prominent role for underlying pathogenesis of a wide range of retinal diseases, including age-related macular degeneration, diabetic retinopathy, retinal vein occlusion, and retinitis pigmentosa, and has suggested a role for anti-inflammatory therapies to potentially alter the severity and course of these eye disorders.
Ocular Inflammation
Ocular inflammation is another important condition which can cause retinal tissue damage and cell dysfunction, leading to ocular disease and vision loss. Controlled inflammatory responses are necessary to heal an injury, however over-activated inflammation is the grounds for many ocular diseases.
Retinal degenerative diseases that result in chronic inflammation accelerate retinal tissue destruction and vision loss. The most chronic retinal diseases, such as diabetic retinopathy, age-related macular degeneration and uveitis, are underlined by retinal inflammation, which contributes to vision impairment and/or loss.
Glaucoma is associated with toxic inflammatory factors leading to cell death and disease progression. Trabecular meshwork dysfunction is likely mediated by oxidative stress and inflammatory responses. Ocular surface inflammation may compromise the cornea, conjunctiva and the trabecular meshwork.
Excitotoxicity, oxidative stress, and neuro-inflammation have the ability to influence one another in a self-sustaining manner, thus functioning as a “neurotoxic triad.”
Holton KF. Micronutrients May Be a Unique Weapon Against the Neurotoxic Triad of Excitotoxicity, Oxidative Stress and Neuroinflammation: A Perspective. Front Neurosci. 2021;15:726457. Published 2021 Sep 22. doi:10.3389/fnins.2021.726457
Inflammation underpins and contributes to the pathogenesis of many retinal degenerative diseases.
Wooff Y, Man SM, Aggio-Bruce R, Natoli R, Fernando N. IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases. Front Immunol. 2019;10:1618. Published 2019 Jul 16. doi:10.3389/fimmu.2019.01618
Research evidence shows that treatments with antioxidants have shown to protect the retinal tissues by combating the oxidative stress.
Oxidative Stress
Oxidative stress is an imbalance between free radicals and antioxidants in your body. Ocular disease forms when the oxidative stress exceed the capacity of the antioxidant and repair system.
Oxidative stress plays a prominent role in the pathogenesis of many degenerative diseases of the retina, such as age-related macular degeneration, cataracts, diabetic retinopathy, retinal vein occlusion, and retinitis pigmentosa.
Oxidative stress damage is an important factor in development of glaucoma, which triggers trabecular meshwork degeneration, which then leads to intraocular hypertension.
Different studies provide cumulating evidence, which supports the association of oxidative stress with different aspects of the neurodegenerative process happening in glaucoma.
An imbalance between defensive antioxidant and free radicals in the body causes oxidative stress which can lead to ocular inflammation.
Treat Simultaneously
In most eye disorders many of the above factors could be at inter play concurrently contributing to cascade of events which can further aggravate the condition. The ideal treatment is to target all the below factors simultaneously which provides a normalizing effect.
Herbal medicines has the advantages of multi-component, multi-pathway and multitarget synergies with fewer adverse effects and more therapeutic effects, compared with the exposure to single target chemical drugs.
Photoreceptors, especially cones, have high energy demands, making them vulnerable to metabolic stress. Metabolic dysfunction of photoreceptors and their supporting retinal pigment epithelium (RPE) is an important underlying cause of degenerative retinal diseases.
Li B, Zhang T, Liu W, et al. Metabolic Features of Mouse and Human Retinas: Rods versus Cones, Macula versus Periphery, Retina versus RPE. iScience. 2020;23(11):101672. Published 2020 Oct 14. doi:10.1016/j.isci.2020.101672
Biomedicine Results With Holistic Therapy
Scientific biomedical research papers have shown and explained the mechanism of actions for the holistic treatment principles offered in Netra Restoration Therapy.
See the list of conditions NRT treats
