Glaucoma is a leading cause of blindness worldwide. It is a group of eye disorders that have few symptoms in their early stages but eventually lead to damage to the optic nerve (the bundle of nerve fibers that carries information from the eye to the brain), which can then lead to vision loss or complete blindness. Open-angle is the most common form and affects approximately 95% of individuals. Open-angle glaucoma initially has no symptoms.
At some point, side (peripheral) vision is lost and without treatment, an individual can become totally blind. Many even continue to experience vision loss even after maintaining normal intraocular pressure.
Optic nerve damage usually occurs in the presence of high eye (intraocular) pressure. However, glaucoma can be diagnosed with normal or even lower than normal eye pressure.
Multiple research studies have shown factors such as reduced ocular blood flow, neurotrophins deprivation, increased oxidative stress, ocular inflammation and excitotoxicity can be contributing to vision loss progression in Glaucoma.
Netra Restoration Therapy helps restore normal blood flow to your eyes, reduce oxidative stress & ocular inflammation and supply essential nutrients to help restore your vision.
Find out if you are a candidate for NRT.
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Glaucoma refers to a collection of diseases whereby increased intraocular pressure adversely impacts the optic nerve, and subsequently, the visual field. However, not all cases of glaucoma are associated with increased intraocular pressure, a subset includes similar optic nerve damage and visual field damage known as normal pressure glaucoma. The collection of glaucomatous diseases is subdivided into open-angle and closed-angle glaucoma, both of which can have primary or secondary causes. Open-angle glaucoma (OAG) is a chronic, progressive, and irreversible multifactorial optic neuropathy that is characterized by open angle of the anterior chamber, typical optic nerve head changes, progressive loss of peripheral vision (typical visual field changes) followed by central visual field loss (blindness) for which intraocular pressure (IOP) is an important risk factor.
Open-angle glaucoma.
Angle-closure glaucoma (also called “closed-angle glaucoma” or “narrow-angle glaucoma”).
This is the most common type of glaucoma. It happens gradually, where the eye does not drain fluid as well as it should (like a clogged drain). As a result, eye pressure builds and starts to damage the optic nerve. This type of glaucoma is painless and causes no vision changes at first.
Some people can have optic nerves that are sensitive to normal eye pressure. This means their risk of getting glaucoma is higher than normal. Regular eye exams are important to find early signs of damage to their optic nerve.
This type happens when someone’s iris is very close to the drainage angle in their eye. The iris can end up blocking the drainage angle. You can think of it like a piece of paper sliding over a sink drain. When the drainage angle gets completely blocked, eye pressure rises very quickly. This is called an acute attack. It is a true eye emergency, and you should call your ophthalmologist right away or you might go blind.
The below factors can also contribute to your Glaucoma progression.
Neuroprotection therapy helps protect neurons in your eye from injury such as from eye pressure elevations. Neurotrophins helps to provide the required neuroprotective therapy which prevents from death of the ganglion cells in your eyes.
Vascular dysregulation means that blood flow is not properly flowing. This causes reduced and unstable oxygen supply to the tissues in the eyes. This in turn causes a cacade of events causing glaucomatous optic neuropathy.
Oxidative stress damage is an important factor in development of glaucoma, which triggers trabecular meshwork degeneration, which then leads to intraocular hypertension. Different studies provide cumulating evidence, which supports the association of oxidative stress with different aspects of the neurodegenerative process happening in glaucoma.
Glaucoma is associated with toxic inflammatory factors leading to cell death and disease progression. Trabecular meshwork dysfunction is likely mediated by oxidative stress and inflammatory responses. Ocular surface inflammation may compromise the cornea, conjunctiva and the trabecular meshwork.
Excitotoxicity is increased levels of glutamate and is seen in Glaucoma patients which cause
retinal ganglion cell (RGC) death. If the toxic effects of glutamate aren't blocked, RGC loss can continue, leading to further visual impairment.
Netra Restoration Therapy provides the following benefits for patients with Glaucoma.
The level of loss of nerve fiber layer and optic nerve atrophy will determine the level of the improvement seen.
Most patients start to see subjective improvements in their vision within just 7 days of starting the NRT treatment.
NRT treatment can stop Glaucoma vision loss progression or considerably reduced to preserve the remaining vision.
NRT treatment improves visual field by reinstating dormant and sub-optimally functioning retinal cells. Without treatment these cells would eventually neurodegenerate and be lost forever.
With NRT treatment most glaucoma patients have shown improvement in their visual acuity by a minimum of 1 to 2 lines in distant and near vision.
Most glaucoma patients treated with NRT treatment have shown marked improvement in their color contrast.
Most glaucoma patients treated with NRT treatment have experienced having brighter vision, a reduction in glare, and blurry/cloudy vision.
Current evidence supporting the role of ocular blood flow (OBF) and oxidative stress in the pathogenesis of glaucomatous damage.
Evidence linking vascular dysregulation and glaucoma, and evaluate the clinical characteristics that might suggest the presence of vascular dysregulation in the glaucoma patient.
Several studies indicate that a perfusion instability, rather than a steady reduction of ocular blood flow, might contribute to glaucomatous optic neuropathy.
Lowering the intraocular pressure with eye drops had been the mainstay for the treatment of Glaucoma.
Increased intraocular pressure is only one of the reason why vision loss happens in glaucomatous eyes.
It is well established that many patients continues to experience Glaucoma disease progression and vision loss despite maintaining lower intraocular pressure.
Do you know people with normal intraocular pressure develop Glaucoma and also people with higher-than-normal intraocular pressure never develop Glaucoma.
If you have been treated for Glaucoma through management of intraocular pressure, then you may be addressing only one of the major risk factors and may continue to experience vision loss.